Many studies can claim to re-invent the wheel, however some times the wheel gets broken.
The role of CD8 T cells may be unclear in MS, are they anti-viral?
The role in most EAE models, I thought was pretty clear, until today.
After years of studies in EAE documenting that blockade of CD8 positive T cells either does nothing or augments EAE, now we find it inhibits EAE.
It is suggested that the CD8 cells help the CD4 cells to become damaging cells. I wonder if this has anything to do with the likelihood that rat macrophages can express CD8!
Is this how Alemtuzumab works?