Pandemic Flu A (H1N1) vaccination does not increase risk of getting MS

Bardage et al. Neurological and autoimmune disorders after vaccination against pandemic influenza A (H1N1) with a monovalent adjuvanted vaccine: population based cohort study in Stockholm, Sweden. BMJ. 2011 Oct 12;343:d5956. doi: 10.1136/bmj.d5956.


OBJECTIVE: To examine the risk of MS in people vaccinated against pandemic influenza A (H1N1) with Pandemrix (GlaxoSmithKline, Middlesex, UK) compared with unvaccinated people over 8-10 months.
DESIGN: Study linking individualised data on pandemic vaccinations to an inpatient and specialist database on healthcare utilisation in Stockholm county.

SETTING: 1 024 019 were vaccinated against H1N1 and 921 005 remained unvaccinated.

RESULTS: Risks for multiple sclerosis remained unchanged.

CONCLUSIONS: Results for the safety of Pandemrix over 8-10 months of follow-up were reassuring -notably, there was no change in the risk for Guillain-Barré syndrome, multiple sclerosis, type 1 diabetes, or rheumatoid arthritis. Relative risks were significantly increased for Bell's palsy, paraesthesia, and inflammatory bowel disease after vaccination, predominantly in the early phase of the vaccination campaign. 

"A reassuring study showing that vaccination against pandemic influenza A does not increase your risk of getting MS. MS'ers with children or siblings, who are increased risk of getting MS, will find this information reassuring."