CCSVI: another independent study

Study objective: To determine if chronic cerebral venous insufficiency (CCSVI) exists in MS'ers using the criteria proposed by Zamboni.

Study design: MS'ers and people with clinically isolated syndrome were matched by age and sex with subjects with migraine or no neurological disease. 

Main study outcome measures: Five parameters of venous outflow used by Zamboni were examined. 

Results: There was no significant difference in the number and type of venous outflow abnormalities in MS'ers compared with controls.

Conclusion: This study does not support the theory that CCSVI exists in MS.

Epub ahead of printMarder et al. No Cerebral or Cervical Venous Insufficiency in US Veterans With Multiple Sclerosis. Arch Neurol. 2011 Aug 8. 

"Another negative, independent, study makes it unlikely that CCSVI is going to fulfill Bradford-Hill's criteria for causation or the clinicopathological entity to be considered a diease."

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